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今月のサイエンス一覧
今月のサイエンス一覧
慶應義塾大学医学部発の、インパクトの高い最新の研究成果を紹介していきます。慶應義塾医学部新聞の協力の下、記事を作成しています。
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- 2024/04
- 1:Clinical Utility of the H2FPEF Score in Patients with Early Atrial Fibrillation
2:The International Association for the Study of Lung Cancer Thymic Epithelial Tumors Staging Project: Proposals for the N and the M Components for the Forthcoming (Ninth) Edition of the TNM Classification of Malignant Tumors.
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- 2024/03
- 1:Independent inhibitory control mechanisms for aggressive motivation and action
2:Cost-Effectiveness of Universal Asymptomatic Preoperative SARS-CoV-2 Polymerase Chain Reaction Screening: A Cost-Utility Analysis
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- 2024/02
- 1:Live Two-way Video Versus Face-to-Face Treatment for Depression, Anxiety, and Obsessive-Compulsive Disorder: A 24-Week Randomized Controlled Trial.
2:Proximal and Distal Bronchioles Contribute to the Pathogenesis of Non-Cystic Fibrosis Bronchiectasis (NCFB).
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- 2023/12
- 1:MRP1-Dependent Extracellular Release of Glutathione Induces Cardiomyocyte Ferroptosis After Ischemia-Reperfusion
2:Assessment of Myocardial 18F-FDG Uptake at PET/CT in Asymptomatic SARS-CoV-2-vaccinated and Nonvaccinated Patients
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- 2023/11
- 1:Shared GABA transmission pathology in dopamine agonist- and antagonist-induced dyskinesia
2:Spatial heterogeneity of bone marrow endothelial cells unveils a distinct subtype in the epiphysis
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- 2023/10
- 1:Telepsychiatry versus face-to-face treatment: systematic review and meta-analysis of randomised controlled trials
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- 2023/09
- 1:Bacteriophage therapy against pathological Klebsiella pneumoniae ameliorates the course of primary sclerosing cholangitis.
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- 2023/08
- 1:Gene therapy ameliorates spontaneous seizures associated with cortical neuron loss in a Cln2R207X mouse model
2:Irreversible covalent Bruton's tyrosine kinase inhibitor, TAS5315 versus placebo in rheumatoid arthritis patients with inadequate response to methotrexate: a randomised, double-blind, phase IIa trial.
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- 2023/07
- 1:Phase 1/2a clinical trial in ALS with ropinirole, a drug candidate identified by iPSC drug discovery.
2:Heart-derived collagen promotes maturation of engineered heart tissue
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- 2023/06
- 1:Transcription of MERVL retrotransposons is required for preimplantation embryo development.
2:Dynamics of AMPA receptors regulate epileptogenesis in patients with epilepsy
3:Sex Difference in Outcomes of Acute Myocardial Infarction in Young Patients.
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- 2023/05
- 1:Chemically defined cytokine-free expansion of human haematopoietic stem cells.
2:Reduced versus maximum tolerated methotrexate dose concomitant with tumor necrosis factor inhibitor in patients with rheumatoid arthritis (MIRACLE): a randomised, open-label, non-inferiority trial.
3:A human induced pluripotent stem cell model from a patient with hereditary cerebral small vessel disease carrying R302Q heterozygous mutation in HTRA1
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- 2023/04
- 1:RIP140 deficiency enhances cardiac fuel metabolism and protects mice from heart failure
2:Common Germline Risk Variants Impact Somatic Alterations and Clinical Features across Cancers.
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- 2023/03
- 1:Microenvironmental modulation in tandem with human stem cell transplantation enhances functional recovery after chronic complete spinal cord injury
2:Subarachnoid hemorrhage triggers neuroinflammation of the entire cerebral cortex, leading to neuronal cell death
3:IDH2 stabilizes HIF-1a-induced metabolic reprogramming and promotes chemoresistance in urothelial cancer
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- 2023/02
- 1:DOCK2 is involved in the host genetics and biology of severe COVID-19.
2:Microbiota imbalance induced by dietary sugar disrupts immune-mediated protection from metabolic syndrome.
3:Cytochrome P450 oxidase 2J inhibition suppresses choroidal neovascularization in mice
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- 2023/01
- 1:Identification of trypsin-degrading commensals in the large intestine.
2:Organoid-on-a-chip model of human ARPKD reveals mechanosensing pathomechanisms for drug discovery.
3:Scleral PERK and ATF6 as targets of myopic axial elongation of mouse eyes.
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- 2022/11
- 1:Impact of Amyloid and Tau PET on Changes in Diagnosis and Patient Management.
2:Identification of Quiescent LGR5+ Stem Cells in the Human Colon
3:Gene therapy using genome-edited iPS cells for targeting alignant glioma
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- 2022/10
- 1:Worksite-based intensive lifestyle therapy has profound cardiometabolic benefits in people with obesity and type 2 diabetes.
2:Cell-matrix interface regulates dormancy in human colon cancer stem cells.
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- 2022/09
- 1:In vivo nanoscopic landscape of neurexin ligands underlying anterograde synapse specification
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- 2022/08
- 1:Proximal-tubule molecular relay from early Protein diaphanous homolog 1 to late Rho-associated protein kinase 1 regulates kidney function in obesity-induced kidney damage.
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- 2022/07
- 1:Omega-3 fatty acid epoxides produced by PAF-AH2 in mast cells regulate pulmonary vascular remodeling
2:Segmentectomy versus lobectomy in small-sized peripheral non-small-cell lung cancer (JCOG0802/WJOG4607L) : a multicentre, open-label, phase 3, randomised, controlled, non-inferiority trial.
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- 2022/06
- 1:A highly photostable and bright green fluorescent protein.
2:Topical pH Sensing NIR Fluorophores for Intraoperative Imaging and Surgery of Disseminated Ovarian Cancer.
3:Dopaminergic dysfunction and excitatory/inhibitory imbalance in treatment-resistant schizophrenia and novel neuromodulatory treatment.
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- 2022/05
- 1:Whole-genome landscape of adult T-cell leukemia/lymphoma.
2:Organoid screening reveals epigenetic vulnerabilities in human colorectal cancer.
3:Research impact analysis of international funding agencies in the realm of allergy and immunology.
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- 2022/04
- 1:Nivolumab Combination Therapy in Advanced Esophageal Squamous-Cell Carcinoma.
2:Coupling of angiogenesis and odontogenesis orchestrates tooth mineralization in mice
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- 2022/03
- 1:Tumor-specific inter-endothelial adhesion mediated by FLRT2 facilitates cancer aggressiveness.
2:Fast and Durable Intraoperative Near-infrared Imaging of Ovarian Cancer Using Ultrabright Squaraine Fluorophores.
3:iPSC-based disease modeling and drug discovery in cardinal neurodegenerative disorders.
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- 2022/02
- 1:Peripheral tolerance by Treg via constraining OX40 signal in autoreactive T cells against desmoglein 3, a target antigen in pemphigus
2:Epithelium Replacement Contributes to Field Expansion of Squamous Epithelium and Ulcerative Colitis-Associated Neoplasia.
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- 2021/12
- 1:Cholesterol 25-hydroxylase is a metabolic switch to constrain T cell-mediated inflammation in the skin.
2:Production of functional oocytes requires maternally expressed PIWI genes and piRNAs in golden hamsters.
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- 2021/11
- 1:Oligodendrocytic Na +-K +-Cl - co-transporter 1 activity facilitates axonal conduction and restores plasticity in the adult mouse brain.
2:Novel bile acid biosynthetic pathways are enriched in the microbiome of centenarians.
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- 2021/10
- 1:CD8+ tissue-resident memory T cells promote liver fibrosis resolution by inducing apoptosis of hepatic stellate cells.
2:De-Escalation of Dual Antiplatelet Therapy in Patients With Acute Coronary Syndromes.
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- 2021/09
- 1:AIM2 regulates anti-tumor immunity and is a viable therapeutic target for melanoma.
2:Current Status of and Perspectives on the Application of Marmosets in Neurobiology.
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- 2021/08
- 1:Neonatal Linear IgA Bullous Dermatosis Mediated by Breast Milk-Borne Maternal IgA.
2:Violet light suppresses lens-induced myopia via neuropsin (OPN5) in mice.
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- 2021/05
- 1:An organoid-based organ-repurposing approach to treat short bowel syndrome.
2:MicroRNA-221 and -222 modulate intestinal inflammatory Th17 cell response as negative feedback regulators downstream of interleukin-23.
3:Long-acting injectable versus oral antipsychotics for the maintenance treatment of schizophrenia: a systematic review and comparative meta-analysis of randomised, cohort, and pre–post studies
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- 2021/04
- 1:RUNX-CBFβ-driven enhancer directs the Irf8 dose-dependent lineage choice between DCs and monocytes.
2:Host-microbe cross-talk governs amino acid chirality to regulate survival and differentiation of B cells.
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- 2021/03
- 1:Wnt Signaling Shapes the Histologic Variation in Diffuse Gastric Cancer
2:Role of CC chemokine receptor 9 in the progression of murine and human non-alcoholic steatohepatitis
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- 2021/02
- 1:Blood and lymphatic systems are segregated by the FLCN tumor suppressor
2:Inhibition of aquaporin-3 in macrophages by a monoclonal antibody as potential therapy for liver injury
3:Anti-senescent drug screening by deep learning-based morphology senescence scoring
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- 2020/12
- 1:An Organoid Biobank of Neuroendocrine Neoplasms Enables Genotype-Phenotype Mapping
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- 2020/11
- 1:Pulmonary arterial hypertension caused by AhR signal activation protecting against colitis.
2:The liver–brain–gut neural arc maintains the Treg cell niche in the gut.
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- 2020/10
- 1:A synthetic synaptic organizer protein restores glutamatergic neuronal circuits
2:Effects of Diet versus Gastric Bypass on Metabolic Function in Diabetes
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- 2020/09
- 1:Salt causes aging-associated hypertension via vascular Wnt5a under Klotho deficiency.
2:Risk of cardiovascular events and death associated with initiation of SGLT2 inhibitors compared with DPP-4 inhibitors: an analysis from the CVD-REAL 2 multinational cohort study.
3:Associations of cardiovascular biomarkers and plasma albumin with exceptional survival to the highest ages.
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- 2020/08
- 1:Aqueous olanexidine versus aqueous povidone-iodine for surgical skin antisepsis on the incidence of surgical site infections after clean-contaminated surgery: a multicentre, prospective, blinded-endpoint, randomised controlled trial
2:Excess tau PET ligand retention in elderly patients with major depressive disorder.
3:Human-specific ARHGAP11B increases size and folding of primate neocortex in the fetal marmoset.
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- 2020/07
- 1:Pathological processes in aqueous humor due to iris atrophy predispose to early corneal graft failure in humans and mice
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- 2020/06
- 1:Landscape and function of multiple mutations within individual oncogenes.
2:Somatic inflammatory gene mutations in human ulcerative colitis epithelium.
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- 2020/05
- 1:Association of soy and fermented soy product intake with total and cause specific mortality: prospective cohort study.
2:An ultra-stable cytoplasmic antibody engineered for in vivo applications.
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- 2020/03
- 1:Adipose tissue NAD(+) biosynthesis is required for regulating adaptive thermogenesis and whole-body energy homeostasis in mice.
2:Visualization of AMPA receptors in living human brain with positron emission tomography
3:Antigen-driven Selection of Antibodies Against SSA, SSB and the Centromere 'Complex', Including a Novel Antigen, MIS12 Complex, in Human Salivary Glands
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- 2020/02
- 1:Identification of a novel arthritis-associated osteoclast precursor macrophage regulated by FoxM1
2:Chromosome Engineering of Human Colon-Derived Organoids to Develop a Model of Traditional Serrated Adenoma
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- 2019/12
- 1:Poly-glycine–alanine exacerbates C9orf72 repeat expansion-mediated DNA damage via sequestration of phosphorylated ATM and loss of nuclear hnRNPA3
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- 2019/11
- 1:Nuclear RNA export factor variant initiates piRNA-guided co-transcriptional silencing
2:Broad Heterochromatic Domains Open in Gonocyte Development Prior to De Novo DNA Methylation
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- 2019/10
- 1:Multi-dimensional analysis identified rheumatoid arthritis-driving pathway in human T cell.
2:Plasmacytoid dendritic cells protect against immune-mediated acute liver injury via IL-35.
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- 2019/09
- 1:Cell-autonomous FLT3L shedding via ADAM10 mediates conventional dendritic cell development in mouse spleen
2:Long-term effectiveness of oral second-generation antipsychotics in patients with schizophrenia and related disorders: a systematic review and meta-analysis of direct head-to-head comparisons
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- 2019/08
- 1:Defining the Independence of the Liver Circadian Clock.
2:Mitochondrial ClpP-Mediated Proteolysis Induces Selective Cancer Cell Lethality.
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- 2019/07
- 1:Development of an immunodeficient pig model allowing long-term accommodation of artificial human vascular tubes
2:Molecular dynamics simulation-guided drug sensitivity prediction for lung cancer with rare EGFR mutations
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- 2019/06
- 1:Serotonin-mediated inhibition of ventral hippocampus is required for sustained goal-directed behavior.
2:Activity-Dependent Secretion of Synaptic Organizer Cbln1 from Lysosomes in Granule Cell Axons.
3:Cardiac Reprogramming Factors Synergistically Activate Genome-wide Cardiogenic Stage-Specific Enhancers.
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- 2019/05
- 1:Gut pathobionts underlie intestinal barrier dysfunction and liver Th17 immune responses in primary sclerosing cholangitis.
2:A serum microRNA classifier for the diagnosis of sarcomas of various histological subtypes.
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- 2019/04
- 1:A defined commensal consortium elicits CD8 T cells and anti-cancer immunity
2:Megakaryocytes and platelets from a novel human adipose tissue-derived mesenchymal stem cell.
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- 2019/03
- 1:Brain regulatory T cells suppress astrogliosis and potentiate neurological recovery.
2:Flow-enhanced vascularization and maturation of kidney organoids in vitro.
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- 2019/02
- 1:IL (Interleukin)-10-STAT3-Galectin-3 Axis Is Essential for Osteopontin-Producing Reparative Macrophage Polarization After Myocardial Infarction
2:Glutamatergic Neurometabolite Levels in Patients with Ultra Treatment-Resistant Schizophrenia: a Cross-sectional 3T Proton MRS study
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- 2018/12
- 1:Landscape of immune microenvironment in hepatocellular carcinoma and its additional impact on histological and molecular classification
2:Glutamatergic Neurometabolite Levels in Patients with Ultra Treatment-Resistant Schizophrenia: a Cross-sectional 3T Proton MRS study
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- 2018/11
- 1:Optogenetic Control of Synaptic AMPA Receptor Endocytosis Reveals Roles of LTD in Motor Learning.
2:Tbx6 Induces Nascent Mesoderm from Pluripotent Stem Cells and Temporally Controls Cardiac versus Somite Lineage Diversification.
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- 2018/10
- 1:Modeling sporadic ALS in iPSC-derived motor neurons identifies a potential therapeutic agent
2:Multi-omics monitoring of drug response in rheumatoid arthritis in pursuit of molecular remission
2:Divergent Routes toward Wnt and R-spondin Niche Independency during Human Gastric Carcinogenesis
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- 2018/09
- 1:Macrophage extracellular trap formation promoted by platelet activation is a key mediator of rhabdomyolysis-induced acute kidney injury
2:Multi-omics monitoring of drug response in rheumatoid arthritis in pursuit of molecular remission
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- 2018/08
- 1:Ectopic upregulation of membrane-bound IL6R drives vascular remodeling in pulmonary arterial hypertension.
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- 2018/07
- 1:Single-cell bioluminescence imaging of deep tissue in freely moving animals.
2:Aortic carboxypeptidase-like protein, a WNT ligand, exacerbates nonalcoholic steatohepatitis
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- 2018/06
- 1:Gold-nanofève surface-enhanced Raman spectroscopy visualizes hypotaurine as a robust anti-oxidant consumed in cancer survival
2:Two Classes of Secreted Synaptic Organizers in the Central Nervous System
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- 2018/05
- 1:CRMP2-binding compound, edonerpic maleate, accelerates motor function recovery from brain damage.
2:NAD(+) Intermediates: The Biology and Therapeutic Potential of NMN and NR
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- 2018/04
- 1:Reconstruction of the Human Colon Epithelium In Vivo
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- 2018/03
- 1:Chromatin remodeler CHD7 regulates the stem cell identity of human neural progenitors.
2:Japan strengthens regenerative medicine oversight.
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- 2018/02
- 1:Direct In Vivo Reprogramming with Sendai Virus Vectors Improves Cardiac Function after Myocardial Infarction2:The C1q complement family of synaptic organizers: not just complementary
2:Ectopic colonization of oral bacteria in the intestine drives T(H)1 cell induction and inflammation
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- 2017/12
- 1:RNA binding proteins and the pathological cascade in ALS/FTD neurodegeneration.
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- 2017/11
- 1:Distinct Roles of Ventromedial versus Ventrolateral Striatal Medium Spiny Neurons in Reward-Oriented Behavior.
2:SMARCB1 is required for widespread BAF complex-mediated activation of enhancers and bivalent promoters.
3:RNA-binding protein Qki5 regulates embryonic neural stem cells through pre-mRNA processing in cell adhesion signaling
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- 2017/08
- 1:MAFB prevents excess inflammation after ischemic stroke by accelerating clearance of damage signals through MSR1
2:Notch-mediated conversion of activated T cells into stem cell memory-like T cells for adoptive immunotherapy
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- 2017/07
- 1:Nivolumab treatment for oesophageal squamous-cell carcinoma: an open-label, multicentre, phase 2 trial
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- 2017/04
- 1:Reelin transiently promotes N-cadherin-dependent neuronal adhesion during mouse cortical development.
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- 2017/03
- 1:Dysfunction of ventrolateral striatal dopamine receptor type 2-expressing medium spiny neurons impairs instrumental motivation
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- 2017/02
- 1:Optical inactivation of synaptic AMPA receptors erases fear memory
2: Brain/MINDS: a Japanese National Brain Project for Marmoset Neuroscience
How can brain mapping initiatives cooperate to achieve the same goal?
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- 2016/12
- 1:Obesity accelerates T-cell senescence in visceral adipose tissue.
2:Exogenous remodeling of lung resident macrophages protects against infectious consequences of bone marrow-suppressive chemotherapy.
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- 2016/11
- 1:Colonic Pro-inflammatory Macrophages Cause Insulin Resistance in an Intestinal Ccl2/Ccr2-Dependent Manner.
2:p38 alpha Activates Purine Metabolism to Initiate Hematopoietic Stem/Progenitor Cell Cycling in Response to Stress.
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- 2016/10
- 1:S Developmental regression of hyaloid vasculature is triggered by neurons.
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- 2016/09
- 1:Generation of a Nonhuman Primate Model of Severe Combined Immunodeficiency Using Highly Efficient Genome Editing.
2:The microbiota in adaptive immune homeostasis and disease.
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- 2016/08
- 1: Structural basis for integration of GluD receptors within synaptic organizer complexes.
2: Image-based detection and targeting of therapy resistance in pancreatic adenocarcinoma.
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- 2016/07
- 1: Tumour resistance in induced pluripotent stem cells derived from naked mole-rats.
2: Transsynaptic Modulation of Kainate Receptor Functions by C1q-like Proteins
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- 2016/06
- 1: Multimodal two-photon imaging using a second harmonic generation-specific dye.
2: SAMD9 mutations cause a novel multisystem disorder, MIRAGE syndrome, and are associated with loss of chromosome 7.
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- 2016/05
- 1: The usefulness of measuring tear periostin for the diagnosis and management of ocular allergic diseases
2: Glutamine Oxidation Is Indispensable for Survival of Human Pluripotent Stem Cells.
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- 2016/04
- 1: Haem-dependent dimerization of PGRMC1/sigma-2 receptor facilitates cancer proliferation and chemoresistance.
2: Mutually repressive interaction between Brn1/2 and Rorb contributes to establishment of neocortical layer 2/3 and layer 4.
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- 2016/03
- 1: Mini-Gut Organoids: Reconstitution of Stem Cell Niche.
2: CLEC-2 in megakaryocytes is critical for maintenance of hematopoietic stem cells in the bone marrow.
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- 2016/02
- 1: Use of Intra-aortic Balloon Pump in a Japanese Multicenter Percutaneous Coronary Intervention Registry.
2: Th17 Cell Induction by Adhesion of Microbes to Intestinal Epithelial Cells
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- 2015/12
- 1: Krimper Enforces an Antisense Bias on piRNA Pools by Binding AGO3 in the Drosophila Germline.
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- 2015/11
- 1: Smad2 and Smad3 Inversely Regulate TGF-beta Autoinduction in Clostridium butyricum-Activated Dendritic Cells.
2: The COUP-TFII/Neuropilin-2 is a molecular switch steering diencephalon-derived GABAergic neurons in the developing mouse brain.
