氏名

林　煜欽
GCOE RA
生理学教室

詳細

参加日：2012年12月11日～2012年12月14日

活動レポート

I am very grateful that GCOE young researcher support plan allow me to participate the 35th annual meeting of the molecular biology society of japan in Fukuoka city. It was my second visit to Fukuoka city and it felt nice to be back again. The 4 days packed MBSJ conference has some revolutionary changes this year. Aside from the digitalize the program and make it easier for participant to follow their schedule, all the poster-presenter was encourage to do three minutes oral presentation. It was quite a opportunity for us to practice oral exam and the experience was very fun. The only imperfection was that the oral presentation was overlap with some lectures that make some of us unable to attend.

So after attending quite interesting lectures, I think Dr. ________ on the research of NANOS2 in the germ cell differentiation interested me the most. She found that Nanos2 knockout would cause sterile in mouse. Without the Nanos2 expression, the cell cycle in the PGC progress and then lead to meiotic division on embryonic day E13. This will future leads to male germ cell pathway and eventually cause apoptosis. She also find out that the target of Nanos2 is most likely to be Dazl, a gene that play the gateway to sexual differentiation of fetal germ cells. Nanos2 suppresses Dazl though associating with 3'UTR and then case degradation. They perform couple of transgenic mouse experiment and found out that the depletion of 3'UTR of Dazl can cause sterile and the meiotic marker Scyp3 were then unable to be detected. Moreover, they also found that Dnd1 directly interact with Nanos 2 and 3 and co-localise with Nanos2 in the P-body. The lost of Dnd1 could cause germ cell lost and occurrence of testicular germ cell tumor. They also showed that the Dnd1-null male gonocytes show similar defects to those of Nanos2-null mouse. Although the actual network of Nanos2 in the germ cell is not fully understood, they have identify the target and the association of Nanos2.

Part from the amazing lectures, it was great fun to visit the industrial booths. It is nice to know how fast the technology has advanced and how fast the troublesome experiments could be performed in half of time it used to be. Not to mention, all the presents the companies has prepared for us. I have managed to draw iPod shuffle on the last day of the conference. Most importantly, we were able to meet up with some of the CEOs to talk about possible collaborations, which will benefits both of us.

When it comes to Fukuoka city, everyone could think about delicious meals! After night after conference, we were able to go through Fukuoka city to try out the local cuisine such as dongotsu ramen, motsu mabe and yadai. The experience was amazing!
I felt really blessed to given this chance to visit Fukuoka city, and I am truly thankful to GCOE to support us as always.