Keio founder Yukichi Fukuzawa born into a samurai family of the Nakatsu clan (now Oita Prefecture, Kyushu). Per his father's duties, the family lives in Osaka.

1835 Keio founder Yukichi Fukuzawa born into a samurai family of the Nakatsu clan (now Oita Prefecture, Kyushu). Per his father's duties, the family lives in Osaka.
1855 Fukuzawa enters Koan Ogata's private school Tekijuku in Osaka, which focuses on Dutch studies.
At Tekijuku, Fukuzawa reads physiology, medicine, physics and chemistry texts in their original languages.
1858 Fukuzawa establishes a school for Dutch studies in Edo (now Tokyo).
1860 Fukuzawa goes on his first official trip overseas, traveling to the United States on the Kanrin Maru, one of Japan's first steam-driven warships.
1862 Fukuzawa sent to Europe as a member of the first Japanese Embassy to Europe.
Fukuzawa tirelessly visits hospitals and welfare facilities across Europe, starting with Paris, London and Berlin.
1863 Fukuzawa's school switches its focus to English studies.
1868 Fukuzawa's school renamed after the Keio Era.
1871 Keio University moves to Mita.
1873 Keio Igakusho (Institute of Medicine) established at Mita, Tokyo. (Closed 1880)
Overseen by headmaster Toan Matsuyama, Igakusho is the precursor to the School of Medicine. Teaching both British and American medicine, the institute produces around 300 doctors in seven years.
1880 Student numbers reduce drastically as a consequence of the Satsuma Rebellion (Seinan Senso).
Fukuzawa considers closing Keio amidst a management crisis, but with the cooperation of his pupils, succeeds in overcoming the crisis and announces the Keio Preservation Bill.
1890 Keio establishes a college. Department of Literature, Department of Economics (precursor to the Faculty of Economics) and Department of Law open. The book Rangaku Kotohajime is republished to celebrate the first General Assembly of the Japan Medical Congress. Fukuzawa writes the preface.
1892 The Institute of Infectious Diseases established with Dr. Shibasaburo Kitasato serving as director.
1893 Dr. Kitasato establishes Tsukushigaoka Yojoen, the first hospital in Japan to specialize in the treatment of tuberculosis, and the precursor to the Kitasato Institute Hospital.
Fukuzawa rallies Kitasato, who has been unhappy since returning from Germany, and establishes the Institute for Infectious Diseases. Tsukushigaoka Yojoen founded the following year at Shiba-Shirokane in Tokyo. In 1914, Kitasato and staff resign from the Institute of Infectious Diseases upon its transfer to the Ministry of Education and establish the Kitasato Institute.
1901 Fukuzawa passes away on February 3.